This booklet provides hands-on information about mainstreaming gender and disability as a strategy to ensure that it occurs throughout the entire science, technology and innovation (STI) sector, and in all aspects of NACI’s day-to-day work, whether it be the work of the Council, the Executive Committee, the Secretariat, or one of the National Advisory Committees. The concept of gender and disability mainstreaming is unpacked within the specific framework of science, mathematics, innovation and technology, and against the backdrop of the national objectives of the improvement of the quality of life of South Africans, the promotion of sustainable economic growth and international competitiveness. Practical mainstreaming tools are provided to enable immediate implementation.